NIH Center for Accelerated Innovations (NCAI) - Funded Projects

Principal Investigator Institution Project Title Technology Type Clinical Area Target Indication Project Description
Principal Investigator Institution Project Title Technology Type Clinical Area Target Indication Project Description
Markowitz, Sanford Case Western Reserve University Inhibitor of 15-PGDH to Accelerate Hematopoietic Reconstitution Following Stem Cell Transplantation Small Molecule Therapeutic Blood Blood Disorders View/Download Project Description
Subauste, Carlos Case Western Reserve University Inhibition of CD40-TRAF signaling for the treatment of vascular inflammatory disorders Small Molecule Therapeutic Blood Vascular Inflammation View/Download Project Description
Gratzl, Miklos Case Western Reserve University Diagnostic Test for Earlier Detection of Cystic Fibrosis Diagnostic Lung Cystic fibrosis View/Download Project Description
Grimburg, Brian Case Western Reserve University Advancing Rapid Malaria Detection Technology Towards Commercialization Diagnostic Blood Malaria View/Download Project Description
Gurkan, Umut Case Western Reserve University HemeChip: Point-of-Care Sickle Cell Disease Diagnosis in Low Resource Settings Diagnostic Blood Sickle Cell Disease View/Download Project Description
Sen Gupta, Anirban Case Western Reserve University Synthetic Platelet Technology Development Combination Product Blood Platelet transfusions View/Download Project Description
von Recum , Horst Case Western Reserve University Preventing Long-term AV Graft Infection Through a Rechargeable Antibiotic Coating Device Cardiovascular Dialysis Access View/Download Project Description
Deschenes, Isabelle Case Western Reserve University IND enabling experiments for Intracellular Sigma Peptide in Acute Myocardial Ischemia Therapeutic Cardiovascular Myocardial Infarction View/Download Project Description
Sahadevan, Jay Case Western Reserve University Smart Catheter for Target Mapping of Atrial Fibrillation  Device Cardiovascular Atrial Fibrillation View/Download Project Description
Durand, Dominique Case Western Reserve University Oropharynx Appliance to Maintain Airway Patency Device Sleep Disorder Obstructive Sleep Apnea View/Download Project Description
Rollins, Andrew Case Western Reserve University Polarization-Sensitive OCT (PSOCT) Image Guidance for RFA Therapy of Atrial Fibrillation Device Cardiovascular Atrial Fibrillation View/Download Project Description
Malik, Punam Cincinnati Children's Hospital Medical Center GMP Production of Viral Vector for Gene Therapy Therapeutic Blood Sickle Cell Disease View/Download Project Description
Zheng, Yi Cincinnati Childrens Hospital Medical Center Novel Anti-Inflamatory Drug Targeting NOX2 in Acute Lung Injury (ALI) Small Molecule Therapeutic Lung Acute Lung Injury View/Download Project Description
Ziady, Assem Cincinnati Childrens Hospital Medical Center Developing biomarker based predictive algorithms for lung disease progression in Cystic Fibrosis Diagnostic/System Lung Cystic Fibrosis View/Download Project Description
Moore, Ryan Cincinnati Childrens Hospital Medical Center Novel Augmented and Virtual Reality Application to Improve Surgical Planning in Pediatric Cardiothoracic Procedures Tool Cardiovascular Cardiac Surgery View/Download Project Description
Jegga, Anil Cincinnati Childrens Hospital Medical Center Repurposing Barasertib for the Treatment of Pulmonary Fibrosis Lung Therapeutic Pulmonary Fibrosis View/Download Project Description
Little, Iris Cincinnati Childrens Hospital Medical Center Application of Combined Flow Pulsations and Acoustic Vibrations for Efficient Airway Secretions Removal Lung Device Various Lung Diseases View/Download Project Description
Cancelas, Jose Cincinnati Children’s Hospital Medical Center Development of a Method to Store Refrigerated Platelets for Human Transfusion Small Molecule Therapeutic Lung Platelet Transfusions View/Download Project Description
Hegde, Rashmi Cincinnati Children’s Hospital Medical Center EYA Inhibitors in the Treatment of Peripheral Vascular Disease and PAH Therapeutic Lung Pulmonary Artery Hypertension View/Download Project Description
Saunthararajah, Yogen Cleveland Clinic Oral THU-Decitabine - a Novel Non-Cytotoxic Epigenetic Therapeutic Small Molecule Therapeutic Blood Sickle Cell Disease View/Download Project Description
Li, Xiaoxia Cleveland Clinic Small Molecule Inhibitors Specific for IL-17A Mediated Pulmonary Inflammation Small Molecule Therapeutic Lung Blood Disorders View/Download Project Description
Gildea, Thomas Cleveland Clinic Custom Patient-Specific Airway Stents Medical Device Lung Airway Stenting View/Download Project Description
Fukamachi, Kiyotaka Cleveland Clinic Motion-Activated System (MAS) to Prevent Chest Tube Clogging Medical Device Blood Thoracic Surgery View/Download Project Description
Gupta, Neetu Cleveland Clinic Small Molecule Inhibitors of Ezrin to Target Inflammation and Airway Contraction in Asthma Small Molecule Drug Lung Asthma View/Download Project Description
Papay, Frank Cleveland Clinic Neuromodulatory Implant Device for the Treatment of Obstructive Sleep Apnea Medical Device Sleep Sleep apnea View/Download Project Description
Roselli, Eric Cleveland Clinic Augmented Visualization for Minimally Invasive Cardiovascular Surgery Medical Device Heart Minimally Invasive Cardiothoracic Surgery View/Download Project Description
Fleischman, Aaron Cleveland Clinic High Resolution Intravascular Ultrasound (IVUS) Device Cardiovascular Coronary, Peripheral Arterial Imaging View/Download Project Description
Gao, Shengqiang Cleveland Clinic ReProx™ Large Bore Vascular Closure Device Device Cardiovascular Interventional, Minimally Invasive Cardiology View/Download Project Description
Muschler, George Cleveland Clinic Cell X™ Device Validation for iPS Clone Selection and Cardiomyocyte Fabrication Tool/Other Cardiovascular Cell-based Myocardial Therapy View/Download Project Description
Ramamurthi, Anand Cleveland Clinic Developing Antibody-targeted nanoparticle-drug conjugates as a non-surgical treatment for AAAs Therapeutic Cardiovascular Aortic Aneurysm View/Download Project Description
Karimov, Jamshid Cleveland Clinic Transcatheter Cardiac De-airing System (TCDS) for Minimally Invasive Cardiac Surgery Device Cardiovascular Cardiac Surgery View/Download Project Description
Roselli, Eric Cleveland Clinic Proximal Hybrid Aortic Stentgraft for Simplified Extended Arch Repair (PHASTER) Device Cardiovascular Endovascular Surgery View/Download Project Description
Prasad, Sathyamangla Cleveland Clinic Small Molecule Therapeutic Targeting PP2A to Treat HF Therapeutic Cardiovascular Heart Failure View/Download Project Description
Navia, Jose Cleveland Clinic Transcatheter mitral repair with Basal-Aneurysm-Subvalvular-Spacer (mBASS) Cardiovascular Device Mitral Valve Disease View/Download Project Description
Breuer, Christopher (formerly Hibino, Narutoshi) Nationwide Children’s Hospital and Medical Center Nanofiber Tissue Engineered Vascular Graft (TEVG) Using 3D Printing Technology Medical Device Heart Vascular Grafts View/Download Project Description
Wertheim, Jason Northwestern University A Synthetic Heparin Derivative that Targets Collagen to Repair Damaged Vasculature After Balloon Angioplasty Therapeutic Cardiovascular Percutaneous Vascular Intervention View/Download Project Description
Arora, Rishi Northwestern University A New Biological Therapy for Atrial Fibrillation Therapeutic Cardiovascular Atrial Fibrillation View/Download Project Description
Richter, Claus-Peter Northwestern University Device for diagnosis of Obstructive Sleep Apnea (OSA) Sleep Disorder Device Obstructive Sleep Apnea View/Download Project Description
Erdal, B. Selnur Ohio State University Lung Texture Score Software for CT Image Analysis Diagnostic Tool Lung Lung Imaging View/Download Project Description
Guerau-de-Arellano, Mireia Ohio State University Inhibition of Arginine Methylation as a Therapy for Asthma Therapeutic Lung Asthma View/Download Project Description
Dasi, Lakshmi Prasad Ohio State University Hyaluronan Enhanced and Biomechanically Designed Trans-catheter Aortic Valve Prosthesis Device Cardiovascular Cardiovascular Surgery View/Download Project Description
Pei, Dehua Ohio State University Calcineurin Inhibitors for Treatment of Acute Respiratory Distress Syndrome Therapeutic Lung Respiratory Disease View/Download Project Description
Nimjee, Shahid Ohio State University Arterial Thrombolysis by VWF Aptamer: Optimizing Dose and Evaluating Toxicity in Mice Therapeutic Blood Ischemic Stroke, Myocardial Infarction View/Download Project Description
Ertin, Emre Ohio State University Ultrawideband Radio-Frequency Imaging Technology for Monitoring Thoracic Fluid Levels, Heart and Lung Motion to Predict Heart Failure Events Cardiovascular Diagnostic and Monitoring System Heart Failure View/Download Project Description
Kent, K. Craig Ohio State University Pericelle: a Nanoparticle Based Perivascular Drug Delivery System to Prevent Stenosis and Failure in Vascular Reconstruction Surgeries Cardiovascular Combination Product Combination Product View/Download Project Description
Oren, Liran U. Cincinnati The Application of Vortex Airflow to Continuous Positive Airway Pressure (CPAP) Device Sleep Disorder Obstructive Sleep Apnea View/Download Project Description
DeMazumder, Deeptanker U. Cincinnati Critical Health Assessment & Outcomes Study/Score (CHAOS) for Improved Risk Stratification of Individuals with Occult Subclinical Critical Illness Cardiovascular Tool (eHealth) Cardiac Risk Stratification View/Download Project Description
Fan, Xudong U. Michigan Micro Gas Chromatography and Breathomics for Acute Point-of-Care Diagnostics in Acute Lung Injury Diagnostic/System Lung Acute Lung Injury View/Download Project Description
Holinstat, Michael U. Michigan Development of a small molecule for treatment of immune thrombocytopenia (ITP) Therapeutic Blood Thrombocytopenia View/Download Project Description
Lawrence, Daniel U. Michigan A Small Molecule Therapeutic for the Treatment of Idiopathic Pulmonary Fibrosis Therapeutic Lung Idiopathic Pulmonary Fibrosis View/Download Project Description
Savastano, Luis U. Michigan Vortex Catheter Technology for Mechanical Thrombectomy Device Cardiovascular Cardiovascular Mechanical Thrombectomy View/Download Project Description
Rubinstein, Jack University of Cincinnati Development of IV Probenecid for Acute Decompensated Heart Failure Small Molecule Therapeutic Heart Heart failure View/Download Project Description